THERESA May told Israel this week it would be wrong to axe the Iran nuclear deal.
But Israeli Prime Minister Benjamin Netanyahu insisted in a conversation with her that it threatened the Jewish state’s very existence.
The British leader, on the other hand, told him that the deal was vital for Middle East security.
And that it neutralised Tehran acquiring nuclear weapons for a decade.
Netanyahu has been one of the most vocal opponents of the 2015 agreement. He told the UN General Assembly last month: “Change it or cancel it. Fix it or nix it.”
According to a Downing Street spokesman, May raised the issue with Netanyahu during a phone call on Monday.
She explained that the “UK remains firmly committed to the deal and that we believe it is vitally important for regional security.”
“She said it was important that the deal is carefully monitored and properly enforced, and that both sides deliver on their commitments,” her spokesman added.
Both countries agreed that the international community “needed to be clear-eyed about the threat that Iran poses to the Gulf and the wider Middle East”.
The clash of views between Britain and Israel came in the week that Donald Trump declared that he will “decertify” the Iran pact, which he has called the “worst deal ever” and threatened to scrap it.
In her phone conversation with Netanyahu, May also said that the bilateral trade relationship between Israel and the UK will go from strength to strength.
She added that discussions had taken place to ensure the “freest possible” post-Brexit trade relationship between the two countries.
The two leaders are expected to meet when Netanyahu visits London next month for the 100th anniversary of the Balfour Declaration.